Symbol
Name
ID

Nphs2
nephrosis 2, podocin
MGI:2157018

Phenotype annotations related to renal/urinary system

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Proteinuria	Focal segmental glomerulosclerosis	Nephrotic syndrome	Stage 5 chronic kidney disease
Disease(s) Associated with NPHS2
nephrotic syndrome type 2

Mouse Phenotypes

renal/urinary system phenotype

abnormal kidney arterial blood vessel morphology

abnormal glomerular capillary endothelium morphology

abnormal glomerular endothelium fenestra morphology

abnormal glomerular capillary morphology

dilated glomerular capillary

abnormal peritubular capillary morphology

kidney hemorrhage

increased mesangial cell number

renal tubular necrosis

increased urine creatinine level

increased urine protein level

albuminuria

abnormal kidney morphology

abnormal kidney cortex morphology

abnormal renal glomerular capsule morphology

abnormal podocyte morphology

abnormal podocyte foot process morphology

fused podocyte foot processes

podocyte foot process effacement

absent podocyte slit diaphragm

decreased podocyte number

podocyte hypertrophy

podocyte microvillus transformation

abnormal renal glomerulus basement membrane morphology

increased renal glomerulus basement membrane thickness

abnormal renal glomerulus morphology

expanded mesangial matrix

mesangiolysis

cortical renal glomerulopathies

glomerulosclerosis

glomerular crescent

renal glomerulus hypertrophy

abnormal renal tubule epithelium morphology

renal interstitial fibrosis

renal tubule atrophy

abnormal renal tubule morphology

abnormal proximal convoluted tubule morphology

dilated proximal convoluted tubule

dilated renal tubule

renal cast

decreased creatinine clearance

kidney failure

Availability

Mouse Genotype

Nphs2^tm1Antc/Nphs2^tm1Antc

Nphs2^tm2.1Antc/Nphs2^tm2.1Antc

Nphs2^tm1Antc/Nphs2^tm3.1Antc
Tg(CAG-cre/Esr1*)86Lbgn/0 (conditional)

Nphs2^tm2.1Antc/Nphs2^tm3.1Antc
Tg(CAG-cre/Esr1*)86Lbgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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